New perspectives of quercetin and vitamin C effects on fibronectin-binding integrins and chemokine receptors in prostate cancer cell lines

Objectives The aim of this study is to investigate the effect two abundant dietary supplements, quercetin and vitamin C on some factors involved in metastasis proliferation prostate cancer, which are resistant conventional chemotherapies late stages. Background Bone brain common sites metastases nevertheless their metastatic pathways not well understood. Methods (75µM) (100 µM) CXCR4, CXCR7 chemokine receptors, α4, α5 β1 integrins, ki-67 marker Vascular endothelial growth factor, VEGF was evaluated using Quantitative Reverse Transcription PCR (RT-qPCR). Results alone different PC3 DU145 cancer cell lines, but sequential combination reduced significantly expression CXCR integrin subunits, Ki-67 markers lines. Conclusion Our results indicated beneficial cells with differential response treatment turn may lead us reach suitable therapeutic outcomes combat (Fig. 3, Ref. 36).